Acridine is an important nucleus in heterocyclic compounds which posses a wide spectrum of pharmacological activities. In this present work novel acridine derivatives containing pyrazole moiety like 3,4,6,7-tetrahydro-3,3,6,6-tetramethyl- 9-(3-(aryl)-1-phenyl-1H-pyrazol-4-yl) acridine-1,8(2H,5H,9H,10H)-diones were synthesized from 5,5-dimethylcyclohexane-1,3- dione with 3-(aryl)-1-phenyl-1H-pyrazole-4-carbaldehyde and ammonium acetate by microwave irradiation method. All the synthesized compounds have been characterized by using elemental analysis, FT-IR, 1H NMR, 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has been checked on thin layer chromatographic plate and HPLC technique. All the synthesized compounds were tested for analgesic and anti-inflammatory activities. These compounds can be further exploited to get the potent lead compounds. The detailed synthesis and the analgesic and anti-inflammatory screening of the new compounds are reported.
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